NMR Research Today is a free monthly online journal that collates and summarizes the latest research about NMR, including details on nuclear magnetic resonance, structural determination, techniques.

A fast and robust 19F NMR-based method for finding new HIV-1 protease inhibitors.

Frutos S, Tarrago T, Giralt E

Institut de Recerca Biomèdica (IRB-PCB), Parc Científic de Barcelona, Josep Samitier, 1-5. E-08028 Barcelona, Spain.

The human immunodeficiency virus (HIV) which encodes, among other indispensable enzymes, an aspartic protease that is essential for viral maturation and replication. Numerous inhibitors of the protease have been developed. However, the eventual resistance of HIV-1 to these drugs implies a continuous battle to develop new inhibitors. Proposed herein is a robust, fast, and reliable method employing (19)F NMR for the evaluation of the inhibitory activity of new compounds against HIV-1 protease.

Published 3 April 2006 in Bioorg Med Chem Lett, 16(10): 2677-81.
Full-text of this article is available online (may require subscription).

© 2005-2008 NMR Research Today. All Rights Reserved.