NMR Research Today is a free monthly online journal that collates and summarizes the latest research about NMR, including details on nuclear magnetic resonance, structural determination, techniques.

In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective.

Henry PG, Adriany G, Deelchand D, Gruetter R, Marjanska M, Oz G, Seaquist ER, Shestov A, Uğurbil K

Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA. henry@cmrr.umn.edu

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Published 8 May 2006 in Magn Reson Imaging, 24(4): 527-39.
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