NMR Research Today is a free monthly online journal that collates and summarizes the latest research about NMR, including details on nuclear magnetic resonance, structural determination, techniques.

Removal of a time barrier for high-resolution multidimensional NMR spectroscopy.

Jaravine V, Ibraghimov I, Orekhov VY

The Swedish NMR Centre at Gothenburg University, Box 465, 40530 Gothenburg, Sweden.

We introduce the recursive multidimensional decomposition (R-MDD) method to speed recording of high-resolution NMR spectra. The measurement time is logarithmically dependent on the sizes of indirect spectral dimensions. R-MDD has the sensitivity and resolution advantages of optimized nonuniform acquisition schemes and is applicable to all types of biomolecular spectra. We demonstrated it for triple resonance experiments on three globular proteins (ubiquitin, azurin and the barstar-barnase complex) of 8-22 kDa.

Published 24 July 2006 in Nat Methods, 3(8): 605-7.
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